US5585089A - Humanized immunoglobulins - Google Patents

Anti-SIRP alpha antibodies as a potential new tool for cancer

Immunohistochemistry and flow cytometry were used to measure CD47 ("don't eat me signal") expression on tumor cells and characterize macrophages in the tumor microenvironment. In vitro engulfment assays and mouse experiments were performed with CD47-blocking antibodies to assess macrophage engulfment of tumor cells, progression of micrometastases in the liver and mouse survival. As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα).

Cd47 immunotherapy

CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. The protein CD47 is expressed in high levels on the surface of many cancer cells, where it acts as a "don't eat me" signal to the immune system's macrophages, commonly known as white blood cells. 2019-12-11 · Up-regulation of an innate immunosuppressive pathway, CD47, the ligand of the negative immune checkpoint regulator SIRPα (signal regulatory protein alpha), was observed in NSCLC tumors during anti-angiogenic therapy.

Immunceller vid cancerterapi och läkemedelstillförsel

by NIH/National Institute of Allergy and Infectious Diseases 2018-12-10 · Michaels, A. D. et al. CD47 blockade as an adjuvant immunotherapy for resectable pancreatic cancer. Clin.

Antibodies targeting human IL1RAP IL1R3 show therapeutic

Inhibitors of the CD47-SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p … 2020-08-01 Introduction: CD47 is an anti-phagocytic ('don't eat me') signal overexpressed in many malignant diseases. It acts as myeloid immune checkpoint and thus has prognostic and therapeutic implications. Areas covered : This review presents and discusses the currently available data on the prognostic role and therapeutic value of CD47 in gastrointestinal tumors. 2017-09-19 As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response.

Whether and how oncogenes contribute to this process are not well understood. In a study of mice, Casey et al. found that the MYC oncogene, which is aberrantly activated in many human cancers, up-regulates the expression of genes encoding proteins that dampen the antitumor Blocking CD47 on MM cells with anti-CD47 mAbs enhanced MM phagocytosis and killing by macrophages, especially in 3DTEBM. These results suggest that anti-CD47 mAbs are applicable for MM treatment, and further studies are warranted to examine the effect of anti-CD47 mAbs as a novel checkpoint immunotherapy to target MM in vivo and in patients. NIH investigators hope CD47 study leads to infectious diseases immunotherapy.
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Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. There are three CD47 antagonists in phase I clinical trials, but their potential efficacies are highly controversial. Recent clinical success of cancer immunotherapy has intensified interest in how tumors normally evade the immune response.

NIH investigators hope CD47 study leads to infectious diseases immunotherapy. by NIH/National Institute of Allergy and Infectious Diseases 2020-04-01 CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα). Inhibitors of the CD47-SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p … The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy As a transmembrane protein, CD47 plays an important role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis, inhibition of NO signal transduction and other related reactions.
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Haematologica, Volume 103, Issue 8 by Haematologica - issuu

Nov 1, 2018 Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces Oct 15, 2014 CD47, a multi-facetted target for cancer immunotherapy Further, cross-linking of CD47 expressed on tumor cells via e.g. TSP-1 can directly Nov 21, 2018 STANFORD, CA (US), November 2018 — A novel immunotherapy appears safe for use in patients with a type of blood cancer called Mar 4, 2019 In particular, cell surface expression of the CD47 protein creates a 'don't Weiskopf, K. Cancer immunotherapy targeting the CD47/SIRPα axis.

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Amyloid beta: struktur, biologi och strukturbaserad terapeutisk

Cancer immunotherapy (sometimes called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the disease.